Project #2294
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#2294 : Gene regulation in yeast quiescence
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Name of Applicant : Gwenael Badis-Breard
Date of application : 27-08-2015
Unit : Genetics of Macromolecular Interactions
Location : 68-04-18
Phone : 01 40 61 33 31
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Project context and summary :

In wild life, yeast cells are able to survive in severe conditions, without nutriment for a long period of time because the cell is able to enter in stationary phase. During this phase, the cell can transform varied sources of energy and pause its growth to preserve the cells from death. It is known that most of genes are downregulated in stationary phase and the cell activity is globally reduced to its strict minimum, while a subset of “specialized” genes is induced to promote survival in extreme conditions. We are analysing the transcriptome of exponentially grown or stationary phase yeasts, investigating different level of regulation.

Related team publications :
Widespread bidirectional promoters are the major source of cryptic transcripts in yeast. Neil H, Malabat C, d'Aubenton-Carafa Y, Xu Z, Steinmetz LM, Jacquier A.Nature. 2009 Feb 19;457(7232):1038-42. doi: 10.1038/nature07747. Epub 2009 Jan 25. PMID: 19169244
Cryptic pol II transcripts are degraded by a nuclear quality control pathway involving a new poly(A) polymerase. Wyers F, Rougemaille M, Badis G, Rousselle JC, Dufour ME, Boulay J, Régnault B, Devaux F, Namane A, Séraphin B, Libri D, Jacquier A. Cell. 2005 Jun 3;121(5):725-37. PMID: 15935759
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Status : Declined

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