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Project #2314
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#2314 : Host microbiota modification by the pathogen Listeria monocytogenes
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Organisms :
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Name of Applicant : Javier Pizarro-Cerda
Date of application : 14-09-2015
Unit : Bacteria-Cell Interactions
Location : Roux
Phone : 37 79
@ Mail : pizarroj@pasteur.fr

Project context and summary :

Listeria monocytogenes is a gram positive facultative intracellular foodborne bacterium responsible for serious clinical manifestations including febrile gastroenteritis, meningitis, encephalitis and maternofetal infections in humans and livestock. Intestinal microbiota plays fundamental roles in the resistance to foodborne infections. Intestinal microbiota commensals protect against pathogens by direct antimicrobial activity through production of bacteriocins, competition for nutrients or binding sites, stimulation of epithelial barrier function, immunomodulation and inhibition of virulence factors expression in gastrointestinal pathogens. On the other side, pathogens have developed tools to avoid commensal-mediated resistance to colonization. Thus, the interplay between gut commensals and L. monocytogenes is critical for the infection and the development of the disease. We have identified a Listeria monocytogenes toxin which modifies the intestinal host microbiota and allows Listeria survival in the intestinal content to later invade the intestine and deeper organs.


Related team publications :
New subject in our lab, there are no relevant related publications (with the exception of general reviews from other investigators in the field, for example: Molloy EM et al 2011 Nat Rev Microbiol)
Service Delivery
Project Manager : amine.ghozlane@pasteur.fr
Project Type : Medium
Status : Closed
Publication : http://www.pnas.org/content/early/2016/04/27/1523899113.full.pdf
Global Satisfaction for this application : Excellent (5/5)


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