Project
Project #2405
Step by step one goes very far
Organisms :
Group : Name of Applicant : Guilhem Janbon Date of application : 24-09-2015 Unit : RNA Biology of Fungal Pathogens Location : Fernbach 4th floor Phone : 8356@ Mail : janbon@pasteur.fr@ PI-Mail : denfert@pasteur.fr
Project context and summary :
The recent analysis of the Cryptococcus neoformans transcriptomes revealed the presence of thousands of lncRNAs. In these yeasts, different types of lncRNAs seem to exist. The ones that are antisense of coding genes (the NATs), the ones that are located between coding genes (the lincRNAs) and some others that seem to result from alternative transcription start site selection. We identified growth conditions under which the expression of some of them is regulated. We have also identified some genes implicated in the regulation of some of these lncRNAs. This project deals with the characterisation of these lncRNAs, the analysis of their regulation and the study of their function in the biology and virulence of this pathogenic yeast.
Related team publications :