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Project #2490
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#2490 : Analyses of SNP diversity of Legionella pneumophila strains
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Name of Applicant : Carmen Buchrieser
Date of application : 16-10-2015
Unit : Biology Of Intracellular Bacteria
Location : Duclaux
Phone : 01 45 68 83 72
@ Mail : cbuch@pasteur.fr

Project context and summary :

Legionella pneumophila is from a genomic point of view a very diverse species, however, only few clones are responsible for over 50% of all human disease cases. Thus we aim to understand the evolution and emergence of these 5 major disease related clones. We have sequenced a large number L. pneumophila strains belonging to these clones and are undertaking comparative and phylogenetic genome analyses.


Related team publications :
Gomez-Valero L, Rusniok C, Rolando M, Neou M, Dervins-Ravault D, Demirtas J, Rouy Z, Moore RJ, Chen H, Petty NK, Jarraud S, Etienne J, Steinert M, Heuner K, Gribaldo S, Médigue C, Glöckner G, Hartland EL, Buchrieser C (2015) Comparative analyses of Legionella species identifies genetic features of strains causing Legionnaires’ disease. Genome Biol. 15(11):505.
Gomez-Valero L, Rusniok C, Jarraud S, Vacherie B, Rouy Z, Barbe V, Medigue C, Etienne J, Buchrieser C (2011) Extensive recombination events and horizontal gene transfer shaped the Legionella pneumophila genomes. BMC Genomics 12:536
Cazalet C, Gomez-Valero L, Rusniok C, Lomma M, Dervins-Ravault D, Newton HJ, Sansom FM, Jarraud S, Zidane N, Ma L, Bouchier C, Etienne J, Hartland EL, Buchrieser C (2010) Analysis of the Legionella longbeachae Genome and Transcriptome Uncovers Unique Strategies to Cause Legionnaires’ Disease. PLoS Genet 6(2): e1000851. IF 7.5
Service Delivery
Project Manager : pierre.lechat@pasteur.fr
Project Type : Medium
Status : Closed
Publication : 27662900
Global Satisfaction for this application : Excellent (5/5)


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