Project #2712
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#2712 : Regulation by phase variation and attenuation: looking for leader peptides containing repeats in the intergenic regions of streptococcal genomes
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Name of Applicant : Shaynoor Dramsi
Date of application : 10-11-2015
Unit : Biology of Gram-Positive Pathogens
Location : Duclaux Aile Fourneau 1st floor room 24
Phone : 01 40 61 32 80
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Project context and summary :

We have described recently a novel mechanism of regulation combining phase variation and attenuation of two pilus operons in Streptococcus gallolyticus . Phase variation occurs  by single-strand mispairing during replication due to the presence of repeats in the leader peptide located immediately upstream of the pilus operon. We wonder if the same mechanism is applicable to other bacterial genes.

Related team publications :
Danne C, Dubrac S, Trieu-Cuot P, Dramsi S*. Single cell stochastic regulation of pilus phase variation by an attenuation-like mechanism. PLoS Pathog. 2014. Jan; 10 (1):e1003860.
Martins M, Aymeric L, du Merle L, Danne C, Robe-Masselot C, Trieu-Cuot P, Sansonetti P, Dramsi S (2015). Streptococcus gallolyticus Pil3 pilus is required for adhesion to colonic mucus and for colonization of mouse distal colon. J Infect Dis [Epub ahead of print].
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Project Type : Medium
Status : Closed

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