Project #2822
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#2822 : sequence conservation in the vicinity of Gli3 binding sites in the mouse genome
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Name of Applicant : ROBERT Benoit
Date of application : 19-11-2015
Unit : Molecular Genetics of Morphogenesis
Location : Calmette 4e room 15
Phone : 0168808965
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Project context and summary :

Gli are transcriptional regulators involved in the Shh signalling pathway. Gli3 binding sites on DNA have been defined in the mouse genome by ChIP-chip experiments (Vokes et al., 2008). We are working on the Msx transcription factor family, and have strong evidence indicative of interactions between Msx1 and Gli3 at the protein level. This might reflect in Msx1 binding to DNA in the vicinity of Gli3 binding sites. However, Msx1 binding sites are ill-defined. One stategy to confirm this hypothesis is to compare sequences around gli3 binding sites (around 4200 such sequences in published data) and look for conserved stretches that might define Msx1 binding sites.

Related team publications :
Lallemand Y, Bensoussan V, Cloment CS, Robert B (2009) Msx genes are important apoptosis effectors downstream of the Shh/Gli3 pathway in the limb. Dev Biol. 331:189-98.
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Project Type : Short
Status : Closed
Global Satisfaction for this application : Excellent (5/5)

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