Project #2882
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#2882 : Deciphering the global response of human macrophages against M. tuberculosis
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Name of Applicant : Ludovic Tailleux
Date of application : 01-12-2015
Unit : Mycobacterial Genetics
Location : Calmette- 3rd floor- Room 14
Phone : 8877
@ Mail :

Project context and summary :

Human macrophages are the main cell target of Mycobacterium tuberculosis (Mtb), the etiologic agent of tuberculosis. Once phagocytosed, bacilli escape bactericidal functions of macrophages and they multiply inside the cell. Understanding interactions between bacilli and human phagocytes is primordial to develop new strategies to combat tuberculosis. We propose a project aiming at deciphering cell-cell communications between infected cells and non-infected cells. We will use the transcriptomic and the proteomic approaches to discriminate the global response of these differents sub-populations. To our knowledge, this work represents the first study that combines two different levels for the identification of a specific response of infected-cells and neighboring non-infected cells. This study would determine cellular markers of a Mtb signature.

Related team publications :
Mycobacterial infection induces a specific human innate immune response. Sci Rep. 2015 Nov 20;5:16882. doi: 10.1038/srep16882. PMID: 26586179
A genomic portrait of the genetic architecture and regulatory impact of microRNA expression in response to infection. Genome Res. 2014 May;24(5):850-9. doi: 10.1101/gr.161471.113. Epub 2014 Jan 30. PMID: 24482540
Deciphering the genetic architecture of variation in the immune response to Mycobacterium tuberculosis infection. Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):1204-9. doi: 10.1073/pnas.1115761109. Epub 2012 Jan 10. PMID: 22233810
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Project Type : Medium
Status : Closed
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