Project #3257
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#3257 : Factors determining HIV seeding in CD4+ T cell subpopulations
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Name of Applicant : Saez Cirion Asier
Date of application : 20-01-2016
Unit : HIV, Inflammation and Persistence
Location : Centre Françoise Jacob, 3 floor
Phone : 8944
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Project context and summary :

The objective of this study is to evaluate how the different programming of distinct CD4+ T cell subsets affected their susceptibility to HIV infection and the survival of infected cells. Dr. Saez-Cirion's Team evaluates how the metabolic state of CD4+ T cells and the regulation of cellular factors shape the distribution of the HIV reservoir in distinct CD4+ T cell subset. This project uses new technologies and reagents to analyze cells from uninfected donors, and from HIV patients in acute infection, chronic infection and HIV remission.

Related team publications :
p21-mediated RNR2 repression restricts HIV-1 replication in macrophages by inhibiting dNTP biosynthesis pathway. Allouch A, David A, Amie SM, Lahouassa H, Chartier L, Margottin-Goguet F, Barré-Sinoussi F, Kim B, Sáez-Cirión A, Pancino G. Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):E3997-4006
Restriction of HIV-1 replication in macrophages and CD4+ T cells from HIV controllers. Sáez-Cirión A, Hamimi C, Bergamaschi A, David A, Versmisse P, Mélard A, Boufassa F, Barré-Sinoussi F, Lambotte O, Rouzioux C, Pancino G; ANRS CO18 Cohort. Blood. 2011 Jul 28;118(4):955-64
Post-treatment HIV-1 controllers with a long-term virological remission after the interruption of early initiated antiretroviral therapy ANRS VISCONTI Study. Sáez-Cirión A, Bacchus C, Hocqueloux L, Avettand-Fenoel V, Girault I, Lecuroux C, Potard V, Versmisse P, Melard A, Prazuck T, Descours B, Guergnon J, Viard JP, Boufassa F, Lambotte O, Goujard C, Meyer L, Costagliola D, Venet A, Pancino G, Autran B, Rouzioux C; ANRS VISCONTI Study Group. PLoS Pathog. 2013 Mar;9(3):e1003211.
Service Delivery
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Project Type : Medium
Status : Closed
Publication : 10.1016/j.cmet.2018.11.015
Global Satisfaction for this application : Excellent (5/5)

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