Project

Project #380
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Topics :

Variant analysis

Organisms :

Bacteria Mycobacterium

Group :

ALPS

Name of Applicant : Maria Virginia BUCHIERI
Date of application : 04-05-2015
Unit : Mycobacterial Genetics
Location : Calmette, gauche (62) > 3ème étage > 02B
Phone : 8840
@ Mail : maria-virginia.buchieri@pasteur.fr

Project context and summary :

Several mycobacterial species have been used for the screening of chemical libraries with the aim of avoiding natural resistance mechanisms developed by specific species. In this way, different compounds with antibacterial activity have been identified. Mutants resistant to each compound have been isolated and their genomes have been sequenced. The comparison of these sequences with the wild type strain genome will allow us to identify the targets for the antibacterial activity and the mechanism of action of the molecules. This will be instrumental for improving molecules for a better antibacterial activity with emphasis on tuberculosis.

Related team publications :

Project Manager : pierre.lechat@pasteur.fr
Project Type : Short
Status : Closed

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