Project #4711
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#4711 : Genomic analysis of small orfs of unknown function
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Name of Applicant : Françoise Norel
Date of application : 09-03-2016
Unit : Macromolecular Systems and Signaling
Location : Darré Borrel 2ème étage
Phone : 0140613122
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Project context and summary :

One project of our laboratory is to characterize the function of small proteins specifically expressed in nongrowing Salmonella cells under the tight control of SigmaS.  Our current works focus on small proteins secreted or targeted to the membrane since their characterization might reveal novel aspects of membrane functions and secretion in persistent bacteria, including pathogens. The proposed project is an extension of a former project on the phylogenetic distribution of the small orfs, and aims at analyzing the genomic context of orthologs.

Related team publications :
Repressor activity of the RpoS/σS-dependent RNA polymerase requires DNA binding. Lévi-Meyrueis C, Monteil V, Sismeiro O, Dillies MA, Kolb A, Monot M, Dupuy B, Duarte SS, Jagla B, Coppée JY, Beraud M, Norel F. Nucleic Acids Res. 2015 Feb 18;43(3):1456-68.
Expanding the RpoS/σS-network by RNA sequencing and identification of σS-controlled small RNAs in Salmonella. Lévi-Meyrueis C, Monteil V, Sismeiro O, Dillies MA, Monot M, Jagla B, Coppée JY, Dupuy B, Norel F. PLoS One. 2014 May 8;9(5):e96918.
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Project Type : Short
Status : Closed
Global Satisfaction for this application : Pretty Good (4/5)

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