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Project #5034
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#5034 : Environmental and human surveillance of polioviruses, VDPVs, and other enteroviruses in Madagascar during the switch from tOPV to bOPV
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Organisms :
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Name of Applicant : Patsy Polston
Date of application : 14-03-2016
Unit : Biology of Enteric Viruses
Location : Henri DARRE 7
Phone : 3321
@ Mail : patsy.polston@pasteur.fr
@ PI-Mail : francis.delpeyroux@pasteur.fr

Project context and summary :

Poliomyelitis has been a major public health concern and currently, efforts are being made towards eradicating wild poliovirus type 2 (WPV2). A global switch from trivalent oral poliovirus vaccine (tOPV) to bivalent oral poliovirus vaccine (bOPV without PV2) is planned to take place this year in countries, like Madagascar, where epidemics of type 2 pathogenic circulating vaccine-derived polioviruses (cVDPVs) occur when low polio vaccine coverage allows the circulation and genetic drift of vaccine attenuated PV2 that can thus become pathogenic. In an attempt to monitor the presence and eventually absence of wild poliovirus 2, environmental and human surveillance will be conducted before, during, and after the switch in two regions in Madagascar. PV2, in particular cVDPVs and other enteroviruses will be genetically characterized. These data will support monitoring efforts and confirm the elimination of type 2 PV strains that have been implicated in outbreaks in this country.


Related team publications :
1. Delpeyroux F et al., 2013, Eradication of poliomyelitis and emergence of pathogenic vaccine-derived polioviruses: from Madagascar to Cameroon
2. Razafindratsimandresy R et al., 2013, Reemergence of recombinant vaccine-derived polioviruses in healthy children, Madagascar
3. Rakoto-Andrianarivelo M et al., 2007, Co-circulation and evolution of polioviruses and species C enteroviruses in a district of Madagascar
Service Delivery
Project Manager : amine.ghozlane@pasteur.fr
Project Type : Medium
Status : Closed
Global Satisfaction for this application : Excellent (5/5)


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