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Project #6333
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#6333 : Identification of new or unexpected pathogens, including viruses, bacteria, fungi and parasites associated with acute or progressive diseases
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Organisms :
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Name of Applicant : Marc ELOIT
Date of application : 27-05-2016
Unit : Biology of Infection
Location : Francois Jacob, 2d floor
Phone : 9216
@ Mail : marc.eloit@pasteur.fr

Project context and summary :

Microbial discovery remains a challenging task for which there are a lot of unmet medical and public health needs. Deep sequencing has profoundly modified this field, which can be summarized in two questions : i) which pathogens or association of pathogens are associated with diseases of unknown etiology and ii) among microbes infecting animal (including arthropod) reservoirs, which ones are able to infect large vertebrates, including humans. We are currently addressing these two questions and our current request comes with the willingness for Institut Pasteur to increase its contribution and visibility of this thematic, in particular in relation with hospitals and the Institut Pasteur International network (IPIN).  We expect to identify new microbes associated with human diseases, and this is expected to pave the way for basic research programs focusing on virulence mechanisms and host specificity, and will also lead to phylogenetic and epidemiological studies (frequency of host infection, mode of transmission etc…), as well as the development of improved diagnostic tests for human infections. Our objective is also to contribute to the efforts of Institut Pasteur in the field of infectious diseases, by building a pipeline, from sample to microbial identification, able to manage large cohorts of samples. This project is currently supported by the LABEX IBEID and the CITECH, and critically requires a bioIT support, justifying this application. Partners include different hospitals including Necker-Enfants malades University Hospital regarding patients with progressive disease, different IPIN laboratories, as well as INRA and CIRAD regarding animal/arthropod reservoirs.


Related team publications :
S. Moutailler, I. Popovici, E. Devillers, M. Vayssier-Taussat, M. Eloit. Diversity of viruses in Ixodes ricinus, and characterization of a neurotropic strain of Eyach virus, New Microbes and New Infections, 2016, Vol. 11, p71–81
Virginie Sauvage, Syria Laperche, Justine Cheval, Erika Muth, Myriam Dubois, Laure Boizeau, Charles Hébert, François Lionnet, Jean-Jacques Lefrère, Marc Eloit. Viral metagenomics applied to blood donors and recipients at high-risk for blood-borne infections, Blood Transfusion, in press
Frémond ML, Pérot P, Muth E, Cros G, Dumarest M, Mahlaoui N, Seilhean D, Desguerre I, Hébert C, Corre-Catelin N, Neven B, Lecuit M, Blanche S, Picard C, Eloit M. Next-Generation Sequencing for Diagnosis and Tailored Therapy: A Case Report of Astrovirus-Associated Progressive Encephalitis. J Pediatric Infect Dis Soc. 2015 Sep;4(3):e53-7.
Service Delivery
Project Manager : thomas.bigot@pasteur.fr
Project Type : Long
Status : In Progress


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