Project #7074
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#7074 : Gene Ontology and sequence analysis of proteomics data on mycolactone effects on dendritic cells.
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Name of Applicant : Jean-David Morel
Date of application : 13-09-2016
Unit : Immunobiology of Infection
Location : Metchnikoff-5th floor-5041
Phone : 0140613892
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Project context and summary :

Mycolactone, the lipid toxin produced by Mycobacterium ulcerans, has recently been shown to target the Sec61 transolcon, blocking protein translocation accross the ER membrane. As Sec61 has also been proposed as a critical mediator in cross-presentation in dendritic cells, this analysis aims to analyse mycolactone effects on the proteome of dendritic cells.

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Project Type : Short
Status : Closed
Publication : 10.1073/pnas.1705242114
Global Satisfaction for this application : Pretty Good (4/5)

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