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Project #7142
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#7142 : Development of a web application and new functionalities for the maintenance and curation of iPPI-DB
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Organisms :
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Name of Applicant : Olivier Sperandio
Date of application : 28-09-2016
Unit : Center for Innovation and Technological Research
Location : metchnikoff / 3eme etage / 3011
Phone : 0140613531
@ Mail : olivier.sperandio@pasteur.fr

Project context and summary :

A new version of the iPPI-DB, a manually curated database that contains the structure, some physicochemical characteristics, the pharmacological data and the profile of the PPI targets of several hundred modulators of protein-protein interactions.

This new version will include:

– A maintenance application that facilitates and automates the updates of the database. The computation of the various physico-chemical properties of the modulators and chemical similarity screening on the Galaxy server of the Institut Pasteur.

– A new target-centric mode, based on the mapping of all druggable cavities at the core of PPI interfaces throughout the Protein Data Bank.


Related team publications :
Labbe, C. M., Laconde, G., Kuenemann, M. A., Villoutreix, B. O. & Sperandio, O. iPPI-DB: a manually curated and interactive database of small non-peptide inhibitors of protein-protein interactions. Drug Discov. Today 18, 958–68 (2013).
Labbe, C. M., Laconde, G., Kuenemann, M. A., Villoutreix, B. O. & Sperandio, O. iPPI-DB: a manually curated and interactive database of small non-peptide inhibitors of protein-protein interactions. Drug Discov. Today 18, 958–68 (2013). 2. Labbe, C. M. et al. iPPI-DB: an online database of modulators of protein-protein interactions. Nucleic Acids Res. (2015). doi:10.1093/nar/gkv982 1) Difficulty to manually maintain annotated data
Kuenemann, M. A., Labbé, C. M., Cerdan, A. H. & Sperandio, O. Imbalance in chemical space: How to facilitate the identification of protein-protein interaction inhibitors. Sci. Rep. 6, 23815 (2016).
Service Delivery
Project Manager : herve.menager@pasteur.fr
Project Type : Long
Status : In Progress


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