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Project #7213
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#7213 : Activation of plasmacytoïd dendritic cells by arenaviruses : transcriptomic analysis
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Name of Applicant : Justine Schaeffer
Date of application : 14-10-2016
Unit : Biology of Viral Emerging Infections
Location : Lyon
Phone : 0437282421
@ Mail : justine.schaeffer@pasteur.fr
@ PI-Mail : sylvain.baize@inserm.fr

Project context and summary :

Lassa virus (LASV) is an arenavirus causing hemorrhagic fever in human. 300 000 to 500 000 cases of LASV infection are reported every year in western Africa, including 5 000 to 6 000 deaths. LASV is highly pathogenic, and no vaccine or treatment is available in endemic areas. LASV pathogenesis mechanisms are not well documented, and further investigations are needed to understand viral and immunological factors involved during infection. As previously shown by studies conducted on patients and non-human primates infected by LASV, type I interferon (IFN-I) is important for an effective response to LASV infection. As plasmacytoid DC are specialized in IFN-I response, they could be important for an efficient response to LASV infection.


Related team publications :
Human dendritic cells infected with the nonpathogenic Mopeia virus induce stronger T-cell responses than those infected with Lassa virus, Pannetier and al., Journal of Virology 2011
Early and strong immune responses are associated with control of viral replication and recovery in lassa virus-infected cynomolgus monkeys, Baize and al., Journal of Virology 2009
Service Delivery
Project Manager : natalia.pietrosemoli@pasteur.fr
Project Type : Short
Status : Closed


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