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Project #7331
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#7331 : Analysis of DNA methylation in the presence and absence of antibiotics in wt and mutant V. cholerae.
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Group : Name of Applicant : zeynep Baharoglu Date of application : 08-11-2016 Unit : Bacterial Genome Plasticity Location : 27-02-03 Phone : 9483@ Mail : baharogl@pasteur.fr@ PI-Mail : mazel@pasteur.fr
Project context and summary :
Thanks to RNA-Seq experiments we identified a new orphan DNA methylase (not associated with a restriction enzyme) that is highly upregulated in the presence of low concentrations of aminoglycosides in V. cholerae. The results allow us to consider a differential DNA methylation profile depending on the environment (with or without antibiotics), which can possibly correspond to a novel epigenetic control of the response.
Related team publications :PMID: 24319148
PMID: 23613664
PMID: 21300836
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Project Manager : claudia.chica@pasteur.frProject Type : MediumStatus : ClosedGlobal Satisfaction for this application : Excellent (5/5)