Project
Project #7413
Step by step one goes very far
Organisms :
Group : Name of Applicant : Erminia Rubino Date of application : 17-11-2016 Unit : Cytokine Signaling Location : Metchnikoff - 5 - 5036 Phone : 0685686622@ Mail : erminia.rubino@pasteur.fr@ PI-Mail : sandra.pellegrini@pasteur.fr
Project context and summary :
We study the regulation of type I interferon (IFN) response in humans and in particular the functioning of a key negative feedback regulator, USP18. A recent article reported on a predicted 897nt-long LincRNA (long intergenic non coding RNA) that may target USP18. We have collected information for this LincRNA (genomic locus, putative transcript variants, sequence similarities with USP18 RNA, predicted ORFs, homologies with other genes, etc). To draw a guideline for wet lab experiments, we need to mine databases on this LincRNA. We expect to find it up-regulated in conditions of inflammation or in specific immune cell subsets, like macrophages. We wish to interrogate existing RNA-seq and Chip-seq human databases to obtain information on expression, transcriptional regulation, function, tissue-specificity or relation with pathological conditions of this LincRNA.
Related team publications :