Project #7413
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#7413 : In silico analyses of a novel LincRNA potentially involved in type I IFN response
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Name of Applicant : Erminia Rubino
Date of application : 17-11-2016
Unit : Cytokine Signaling
Location : Metchnikoff - 5 - 5036
Phone : 0685686622
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Project context and summary :

We study the regulation of type I interferon (IFN) response in humans and in particular the functioning of a key negative feedback regulator, USP18. A recent article reported on a predicted 897nt-long LincRNA (long intergenic non coding RNA) that may target USP18. We have collected information for this LincRNA (genomic locus, putative transcript variants, sequence similarities with USP18 RNA, predicted ORFs, homologies with other genes, etc). To draw a guideline for wet lab experiments, we need to mine databases on this LincRNA. We expect to find it up-regulated in conditions of inflammation or in specific immune cell subsets, like macrophages. We wish to interrogate existing RNA-seq and Chip-seq human databases to obtain information on expression, transcriptional regulation, function, tissue-specificity or relation with pathological conditions of this LincRNA.

Related team publications :
Human USP18 deficiency underlies type 1 interferonopathy leading to severe pseudo-TORCH syndrome. Meuwissen et al. J Exp Med. 2016 Jun 27;213(7):1163-74. doi: 10.1084/jem.20151529.
Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation. Zhang et al. Nature. 2015 Jan 1;517(7532):89-93. doi: 10.1038/nature13801.
USP18 establishes the transcriptional and anti-proliferative interferon α/β differential. Francois-Newton et al. Biochem J. 2012 Sep 15;446(3):509-16. doi: 10.1042/BJ20120541.
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Project Type : Short
Status : Closed
Global Satisfaction for this application : Not so great (2/5)

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