Project #7429
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#7429 : A novel MacSyFinder module for detection of bacterial capsule systems on the future Galaxy platform.
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Name of Applicant : Eduardo Rocha
Date of application : 22-11-2016
Unit : Microbial Evolutionary Genomics
Location : FJ - 6eme
Phone : 0140613353
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Project context and summary :

Extracellular capsules constitute the outermost layer of some bacteria and establish the first contact between the cell and its environment. They are major virulence factors involved, amongst other, in antibiotic tolerance and immune escape. Bacterial capsules are also known to mediate unspecific cell-to-cell interactions between and across species and affect population structure and dynamics. Despite the great number of studies characterizing capsule diversity and their role during infection in a few model species, most evolutionary and ecological questions have yet to be adressed. Furthermore, there is no tool to identify and annotate capsule systems across all prokaryotic genomes. We have built such a tool and would like to make it available.

Related team publications :
Breurec S, Criscuolo A, Diancourt L, Rendueles O, Vandenbogaert M, Passet V, Caro V, Rocha EPC, Touchon M, Brisse S. (2016) Genomic epidemiology and global diversity of the emerging bacterial pathogen Elizabethkingia anophelis. Sci Rep. 6:30379
Abby SS, Néron B, Ménager H, Touchon M, Rocha EPC (2014) MacSyFinder: a program to mine genomes for molecular systems with an application to CRISPR-Cas systems. PLoS One 9: e110726.
Abby SS, Cury J, Guglielmini J, Néron B, Touchon M, Rocha EPC (2016) Identification of protein secretion systems in bacterial genomes. Sci Rep 6:23080.
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Project Type : Short
Status : Closed
Global Satisfaction for this application : Excellent (5/5)

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