Project #7836
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#7836 : Graphical representation of co-expressed genes in various datasets
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Name of Applicant : PANTHIER Jean-Jacques
Date of application : 08-02-2017
Unit : Mouse Functional Genetics
Location : Metchnikoff -1
Phone : 01458555
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Project context and summary :

We have identified a candidate gene associated with increased resistance to a pathogen. This gene is poorly annotated in public databases. To get insight into its function we are focusing on genes that are co-expressed with this candidate gene in various datasets, including microarray collection on various mouse tissues or in a given tissue across inbred strains of mice. Indeed, coexpression is one of the central idea in gene expression analysis. The 'Guilt by association' principle states that gene coexpression might indicate shared regulatory mechanisms and roles in related biological processes. We have established lists of genes that are co-expressed in various tissues, and in collection of individuals with different genotypes. We are willing to get graphical representation giving a compact overview of genes that are coexpressed with our candidate gene.

Related team publications :
The genetic basis for susceptibility to Rift Valley fever disease in MBT/Pas mice. Tokuda S, Do Valle TZ, Batista L, Simon-Chazottes D, Guillemot L, Bouloy M, Flamand M, Montagutelli X, Panthier JJ. Genes Immun. 2015 Apr-May;16(3):206-12.
Tissue tropism and target cells of NSs-deleted rift valley fever virus in live immunodeficient mice. Gommet C, Billecocq A, Jouvion G, Hasan M, Zaverucha do Valle T, Guillemot L, Blanchet C, van Rooijen N, Montagutelli X, Bouloy M, Panthier JJ. PLoS Negl Trop Dis. 2011 Dec;5(12):e1421.
A new mouse model reveals a critical role for host innate immunity in resistance to Rift Valley fever. do Valle TZ, Billecocq A, Guillemot L, Alberts R, Gommet C, Geffers R, Calabrese K, Schughart K, Bouloy M, Montagutelli X, Panthier JJ. J Immunol. 2010 Nov 15;185(10):6146-56.
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Project Type : Short
Status : Closed

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