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Project #7990
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#7990 : MacSyDBCapsule
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Name of Applicant : Eduardo Rocha
Date of application : 03-03-2017
Unit : Microbial Evolutionary Genomics
Location : FJ-6
Phone : 3353
@ Mail : erocha@pasteur.fr

Project context and summary :

Extracellular capsules constitute the outermost layer of some bacteria and establish the first contact between the cell and its environment. They are major virulence factors involved, amongst other, in antibiotic tolerance and immune escape. Bacterial capsules are also known to mediate unspecific cell-to-cell interactions between and across species and affect population structure and dynamics. Despite the great number of studies characterizing capsule diversity and their role during infection in a few model species, most evolutionary and ecological questions have yet to be adressed. Furthermore, there is no tool to identify and annotate capsule systems across all prokaryotic genomes. Our previous project led to the installation of our tool on the Galaxy Server. The goal now is to put the data of our survey (>2000 genomes) for the capsule available to the community.


Related team publications :
Abby SS, Néron B, Ménager H, Touchon M, Rocha EPC (2014) MacSyFinder: a program to mine genomes for molecular systems with an application to CRISPR-Cas systems. PLoS One 9: e110726.
Abby SS, Cury J, Guglielmini J, Néron B, Touchon M, Rocha EPC (2016) Identification of protein secretion systems in bacterial genomes. Sci Rep 6:23080.
Service Delivery
Project Manager : bertrand.neron@pasteur.fr
Project Type : Short
Status : Closed
Publication : https://doi.org/10.1371/journal.ppat.1006525
Global Satisfaction for this application : Excellent (5/5)


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