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Project #8227
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#8227 : TB drugs and host response
Topics :
Organisms :
Group :
Name of Applicant : Ludovic Tailleux
Date of application : 27-04-2017
Unit : Integrated Mycobacterial Pathogenomics,Mycobacterial Genetics
Location : Calmette – 3rd floor – room 3
Phone : 0145688877
@ Mail : tailleux@pasteur.fr

Project context and summary :

Tuberculosis (TB), which is caused by Mycobacterium tuberculosis (MTB), is the deadliest disease due to a single infectious agent. Despite considerable efforts to fight the disease, TB remains a major public health problem. Even more worrying for the future, multidrug resistant (MDR) strains of MTB are continually emerging and about 10% of people with MDR-TB have extensively drug-resistant TB (XDR-TB). Drug-sensitive TB can be cured by a 6-month treatment using 4 antibiotics, but MDR-TB and extensively drug-resistant XDR-TB require treatment for up to 2 years with more toxic and costly second- and third-line drugs. Toxicity of these drugs is well described; it includes hepatotoxicity, liver injury, skin reactions, gastrointestinal and neurological disorders. However how MTB drugs influence the host response to MTB infection has been poorly addressed. The main goal of project is to understand how drugs interact with the host in order to improve the treatment.


Related team publications :
Bacterial infection remodels the DNA methylation landscape of human dendritic cells. Pacis A, Tailleux L, Morin AM, Lambourne J, MacIsaac JL, Yotova V, Dumaine A, Danckaert A, Luca F, Grenier JC, Hansen KD, Gicquel B, Yu M, Pai A, He C, Tung J, Pastinen T, Kobor MS, Pique-Regi R, Gilad Y, Barreiro LB. Genome Res. 2015 Dec;25(12):1801-11.
Bacterial infection drives the expression dynamics of microRNAs and their isomiRs. Siddle KJ, Tailleux L, Deschamps M, Loh YH, Deluen C, Gicquel B, Antoniewski C, Barreiro LB, Farinelli L, Quintana-Murci L. PLoS Genet. 2015 Mar 20;11(3):e1005064.
Deciphering the genetic architecture of variation in the immune response to Mycobacterium tuberculosis infection. Barreiro LB, Tailleux L, Pai AA, Gicquel B, Marioni JC, Gilad Y. Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):1204-9.
Service Delivery
Project Manager : anne.biton@pasteur.fr
Project Type : Short
Status : Awaiting Publication


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