Project #8364
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#8364 : Assess possible correlations between enteric viruses found in sewage waste water and healthy Roma children in Romania in the period 2016-2017
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Name of Applicant : Amrish Baidjoe
Date of application : 30-05-2017
Unit : Biology of Enteric Viruses
Location : Darre (59) - 2nd floor
Phone : 0643522803
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Project context and summary :

Enteroviruses are among the most common viruses infecting humans and can cause diverse clinical syndromes ranging from minor febrile illness to severe and potentially fatal diseases. Among them, polioviruses (PVs) are the etiologic agent of paralytic poliomyelitis, a disease characterised by acute flaccid paralysis due to the destruction of motor neurons following PV replication. Thanks to the high coverage rate within the different contries, the WHO European region was certified polio-free more than 10 years ago. However, some communities feature a low coverage rate due to their refusal of vaccination for religious reasons or to the difficulties they encounter to benefit from the public health system.   The Cantacuzene institute (Bucarest, Romania) and the Enteric Virus Biology Unit of the Institut Pasteur are part of the WHO Global Polio Laboratory Network that is in charge of the PV surveillance worldwide. In 2015, the environmental surveillance was enhanced in Romania because the risk of poliomyelytis outbreak was considered high: first, the country shares a border with Ukraine, a country that has a inadequate vaccination coverage according to WHO standards; besides, the members of the Roma community of Romania mainly remains unvaccinated, thus making this community highly susceptible to poliomyelitis outbreaks. For these reasons the Cantacunzene institute has conducted since 2015 an extensive surveillance of PV circulation through collections of sewage water samples. These samples were collected in regions bordering Ukraine and in Bucharest, Constanta and Tulcea. All these samples were investigated for the presence of PVs. Some of them were found to contain non-PV enteroviruses that were not studied further by the Cantacuzene institute.   The non-PV enteroviruses isolated in the framework of PV surveillance constitute a precious material to study the circulation of enteroviruses. Our project aims to characterize a panel of non-PV enteroviruses isolated in Romania. These viruses will be sent to the Enteric Virus Biology Unit of the Institut Pasteur. Molecular methods will be used to type the viruses and to determine their whole genomic sequences. These sequences will be compared to those of enteroviruses isolated elsewhere in Europe to determine whether enteroviruses constitute many regional ecosystems that evolve separately, or whether these viruses circulate through all Europe. Our results will give us an overview of the diversity of the enteroviruses that currently circulate in Romania and will provide information about the molecular epidemiology of these viruses in this country and in Europe.

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Project Type : Short
Status : Closed
Global Satisfaction for this application : Excellent (5/5)

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