Project #8494
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#8494 : NOXO1 interacting partners in intestinal epithelial cells under inflammatory and infectious conditions
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Name of Applicant : Benoit MARTEYN
Date of application : 21-06-2017
Unit : Molecular Microbial Pathogenesis
Location : Duclaux, Aile Bertrand, 1st floor
Phone : 0699132323
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@ PI-Mail :

Project context and summary :

Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (or NOX) are a unique family of enzymes dedicated to the production of reactive oxygen species (ROS) such as superoxide anion (O.-2) and hydrogen peroxide (H2O2) (1). This family includes NOX1-5, DUOX1 and DUOX2 and has been defined on the basis of its members’ structural homology with gp91PHOX (now renamed NOX2), the catalytic core of the phagocyte NADPH oxidase. A functional phagocytic NADPH oxidase complex consists of the membrane-anchored flavocytochrome b558 (the catalytic core of the enzyme composed of gp91PHOX and p22PHOX), the regulatory cytosolic proteins p47PHOX, p67 PHOX, p40 PHOX, and the low molecular-weight GTP-binding proteins, Rac 1 or 2 [3]. NADPH oxidase 1 (NOX1), the first homologue of gp91PHOX identified in colon epithelial cells, is the NOX family member most closely related to phagocytic NADPH oxidase in terms of its structure and function [2]. NOX1, NOXO1 and NOXA1 transcripts are abundantly expressed in the colon where they could be involved in mucosal innate immunity under physiological conditions [4]. During inflammatory and infectious conditions NOXO1 is the mostly upregulated subunit [5-6].    

  1. Lambeth JD. (2004). Nat. Rev. Immunol. 4: 181-189.
  2. Bedard K, Physiol Rev. 87: 245-313.
  3. Dang PM,. Proc Natl Acad Sci U S A. 98: 3001-3005.
  4. Rokutan K,. Antioxid Redox Signal. 8: 1573-1582.
  5. Mouzaoui S, Mediators Inflamm. 2014:312484
  6. Elatrech I. Inflammatory Bowel Diseases.21:1018-

Related team publications :
Lambeth JD. (2004). Nat. Rev. Immunol. 4: 181-189.
Dang PM,. Proc Natl Acad Sci U S A. 98: 3001-3005.
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Project Type : Short
Status : Closed

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