Project
Project #8788
Step by step one goes very far
Organisms :
Group : Name of Applicant : Xian Hao Date of application : 22-08-2017 Unit : Imaging and Modeling Location : Monod (66)-Ground floor-10 Phone : +33685869540@ Mail : xian.hao@pasteur.fr@ PI-Mail : christophe.zimmer@pasteur.fr
Project context and summary :
Chromosomes are arranged non-randomly in the 3D space of cellular nuclei. This architecture is important to key biological processes including gene expression and DNA repair, but remains poorly understood in detail. Genome-wide chromosome conformation capture (Hi-C) is currently the most powerful experimental technique to probe chromosomal structures. However, this technique does not directly provide a description of high-resolution chromosomal configurations in individual cells and remains blind to the dynamics of chromatin in live cells. In this research, we developed experimental imaging and associated computational approaches to describe the structures of chromosomes at high resolution in individual cells.
Related team publications :