Project #9210
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#9210 : Effects of expanded-spectrum cephalosporins ( ceftriaxone or céfotaxime) on the human gut Mycobiome
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Name of Applicant : Marie-Elisabeth Bougnoux
Date of application : 11-09-2017
Unit : Fungal Biology and Pathogenicity
Location : Fernbach 68
Phone : 0140613126
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Project context and summary :

The gastrointestinal tract of humans is colonized by hundreds of microbial species, - bacteria, archaebacterial, fungi, protozoa and viruses -, collectively named the gut microbiome. The intestinal commensal bacteria have an important role in metabolic processes and contribute to colonization resistance against intestinal pathogens. Fungi are usually considered to be a minor component of the global microbiome. However, the mycobiome (fungal component of the entire microbiome) has been in fact little studied particularly with regards to its relationships with the other components of the microbiome. Fungi could be important players of the microbiome because some fungal species are able to proliferate in response to diet or during dysbiosis due to antibiotic treatment or gut inflammation. The aim of this project is to investigate the effect of specific antibiotics (primarily anti-Gram negative bacteria antibiotic) on the gut mycobiome. More specifically, we will examine the impact of cefotaxime and ceftriaxone, 2 antibiotics with same antimicrobial spectra but different rates of biliary elimination, on the changes in fungal communities.

Related team publications :
Unexpected persistence of extended-spectrum β-lactamase-producing Enterobacteriaceae in the faecal microbiota of hospitalised patients treated with imipenem. Grall N, Lazarevic V, Gaïa N, Couffignal C, Laouénan C, Ilic-Habensus E, Wieder I, Plesiat P, Angebault C, Bougnoux ME, Armand-Lefevre L, Andremont A, Duval X, Schrenzel J. Int J Antimicrob Agents. 2017 Jul;50(1):81-87
Candida albicans commensalism in the gastrointestinal tract. Neville BA, d'Enfert C, Bougnoux ME. FEMS Yeast Res. 2015 Nov;15(7)
Angebault C, Djossou F, Abélanet S, Permal E, Ben Soltana M, Diancourt L, Bouchier C, Woerther PL, Catzeflis F, Andremont A, d'Enfert C, Bougnoux ME. J Infect Dis. 2013 Nov 15;208(10):1705-16.
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Project Type : Short
Status : Awaiting Publication

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