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Training
Starting Tue 24 Oct 2017 at 08:00 am, Valerie Crecy-Lagard will organize Linking gene and function, comparative genomics tools for biologists.

More than twenty years after the first bacterial genome has been sequenced, microbiologists are faced with an avalanche of genomic data. However the quality of the functional annotations of the sequenced proteome is very poor with more than half of the sequenced proteins remaining of unknown function. After taking this…
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Training
Starting Mon 16 Oct 2017 at 09:00 am, c3bi team will organize Introduction to data analysis 2017-18

This five weeks graduate level course will give participants basic skills and hands-on training in biostatistics. It will cover all the steps of an analysis workflow : design, collection, curation, hypothesis testing and data mining. The course can be divided into four different topics whose practice is mandatory for those…
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Publication – Emerging Infectious Diseases
Real-time whole-genome sequencing for surveillance of Listeria monocytogenes, France. – Moura A, Tourdjman M, Leclercq A, Hamelin E, Laurent E, Fredriksen N, Van Cauteren D, Bracq-Dieye H, Thouvenot P, Vales G, Tessaud-Rita N, Maury MM, Alexandru A, Criscuolo A, Quevillon E, Donguy MP, Enouf V, de Valk H, Brisse S, Lecuit M.

During 2015-2016, we evaluated the performance of whole-genome sequencing (WGS) as a routine typing tool. Its added value for microbiological and epidemiologic surveillance of listeriosis was compared with that for pulsed-field gel electrophoresis (PFGE), the current standard method. A total of 2,743 Listeria monocytogenes isolates collected as part of routine…
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Training
Starting Mon 6 Nov 2017 at 09:00 am, C3BI Training will organize C3BI Hands-on NGS course Hong-Kong 2017

This theoretical and practical course is aimed at researchers who would like to get the most out of their Next Generation Sequencing datasets. We will tackle several topics, encompassing theoretical NGS approaches and statistical analysis of NGS data. Ultimately, we want this course to be of immediate value to the students. The first…
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Available position
10 postes (CDI) de bioinformaticiens/biostatisticiens (H/F) – application ends Wed 6 Sep 2017

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Training
Starting Mon 25 Sep 2017 at 10:00 am, Gregorio Iraola will organize Hands-on Metagenomics data analysis: tools for bioprospection in clinical and environmental microbiology

The main objective of this training course is to provide the trainees: i) a concise theoretical framework of the state-of-the-art methodologies and analytical approaches to analyse metagenomic high-throughput data and ii) help and assist the trainees during intensive hands-on sessions to apply these methodologies on their own real datasets and…
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Publication – Nature Communication
Evolutionary dynamics and genomic features of the Elizabethkingia anophelis 2015 to 2016 Wisconsin outbreak strain. – Perrin A, Larsonneur E, Nicholson AC, Edwards DJ, Gundlach KM, Whitney AM, Gulvik CA, Bell ME, Rendueles O, Cury J, Hugon P, Clermont D, Enouf V, Loparev V, Juieng P, Monson T, Warshauer D, Elbadawi L, Walters MS, Crist MB, Noble-Wang J, Borlaug G, Rocha EPC, Criscuolo A, Touchon M, Davis JP, Holt KE, McQuiston JR, Brisse S

An atypically large outbreak of Elizabethkingia anophelis infections occurred in Wisconsin. Here we show that it was caused by a single strain with thirteen characteristic genomic regions. Strikingly, the outbreak isolates show an accelerated evolutionary rate and an atypical mutational spectrum. Six phylogenetic sub-clusters with distinctive temporal and geographic dynamics…
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Publication – Scientific Reports
Proteome remodelling by the stress sigma factor RpoS/σS in Salmonella: identification of small proteins and evidence for post-transcriptional regulation – Lago M, Monteil V, Douche T, Guglielmini J, Criscuolo A, Maufrais C, Matondo M, Norel F

The RpoS/σS sigma subunit of RNA polymerase is the master regulator of the general stress response in many Gram-negative bacteria. Extensive studies have been conducted on σS-regulated gene expression at the transcriptional level. In contrast, very limited information regarding the impact of σS on global protein production is available. In…
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News
Mon 30 Jan 2017 – Inauguration du C3BI