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Publication – Scientific Reports
Proteome remodelling by the stress sigma factor RpoS/σS in Salmonella: identification of small proteins and evidence for post-transcriptional regulation – Lago M, Monteil V, Douche T, Guglielmini J, Criscuolo A, Maufrais C, Matondo M, Norel F

The RpoS/σS sigma subunit of RNA polymerase is the master regulator of the general stress response in many Gram-negative bacteria. Extensive studies have been conducted on σS-regulated gene expression at the transcriptional level. In contrast, very limited information regarding the impact of σS on global protein production is available. In…
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Seminar
Thu 8 Jun 2017 at 02:00 pm, Mathieu Blanchette will talk about Know Thy Ancestors to Know Thyself: Improving Our Understanding of the Human Genome Using Computational Paleogenomics

Know Thy Ancestors to Know Thyself: Improving Our Understanding of the Human Genome Using Computational Paleogenomics The genomes of more than one hundred vertebrate genomes are now largely sequenced. How can one make use of this massive amount of evolutionary information to better understand the origin and function of portions of…
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Publication – Pathogens and Disease
Molecular characterization of Chlamydia pneumoniae associated to atherosclerosis. – Yazouli LE, Criscuolo A, Hejaji H, Bouaaza M, Elmdaghri N, Alami AA, Amraoui A, Dakka N, Radouani F

Chlamydia pneumoniae is a respiratory pathogen associated with chronic inflammatory diseases such as asthma and atherosclerosis, and its detection in human carotid and coronary atheroma suggests some support for its involvement in atherogenesis. The main objective of our study was to evaluate the association between Chlamydia pneumoniae and atherosclerosis in…
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Publication – Nature Microbiology
N-terminomics identifies Prli42 as a membrane miniprotein conserved in Firmicutes and critical for stressosome activation in Listeria monocytogenes – Impens F, Rolhion N, Radoshevich L, Bécavin C, Duval M, Mellin J, García Del Portillo F, Pucciarelli MG, Williams AH, Cossart P

To adapt to changing environments, bacteria have evolved numerous pathways that activate stress response genes. In Gram-positive bacteria, the stressosome, a cytoplasmic complex, relays external cues and activates the sigma B regulon. The stressosome is structurally well-characterized in Bacillus, but how it senses stress remains elusive. Here, we report a…
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News
Mon 30 Jan 2017 – Inauguration du C3BI

Seminar
Thu 15 Jun 2017 at 02:00 pm, Julien Dutheil will talk about Between chaos and determinism: the evolution of stochastic gene expression

Between chaos and determinism: the evolution of stochastic gene expression While often depicted as finely tuned programs, biochemical processes in the cell are subject to random fluctuations because of the small number of molecules involved. While this phenomenon was long recognised, it was only recently assessed at a genomic scale. In…
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Seminar
Thu 1 Jun 2017 at 02:00 pm, Julien Gagneur will talk about Genetic basis of gene regulation: genome-wide models and applications to diagnosis.

Genetic basis of gene regulation: genome-wide models and applications to diagnosis….
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