News

All News Seminars Trainings Publications
All latest news

Seminar
Thu 8 Jun 2017 at 02:00 pm, Mathieu Blanchette will talk about Know Thy Ancestors to Know Thyself: Improving Our Understanding of the Human Genome Using Computational Paleogenomics

Know Thy Ancestors to Know Thyself: Improving Our Understanding of the Human Genome Using Computational Paleogenomics The genomes of more than one hundred vertebrate genomes are now largely sequenced. How can one make use of this massive amount of evolutionary information to better understand the origin and function of portions of…
read more

Publication – Pathogens and Disease
Molecular characterization of Chlamydia pneumoniae associated to atherosclerosis. – Yazouli LE, Criscuolo A, Hejaji H, Bouaaza M, Elmdaghri N, Alami AA, Amraoui A, Dakka N, Radouani F

Chlamydia pneumoniae is a respiratory pathogen associated with chronic inflammatory diseases such as asthma and atherosclerosis, and its detection in human carotid and coronary atheroma suggests some support for its involvement in atherogenesis. The main objective of our study was to evaluate the association between Chlamydia pneumoniae and atherosclerosis in…
read more

Publication – Nature Microbiology
N-terminomics identifies Prli42 as a membrane miniprotein conserved in Firmicutes and critical for stressosome activation in Listeria monocytogenes – Impens F, Rolhion N, Radoshevich L, Bécavin C, Duval M, Mellin J, García Del Portillo F, Pucciarelli MG, Williams AH, Cossart P

To adapt to changing environments, bacteria have evolved numerous pathways that activate stress response genes. In Gram-positive bacteria, the stressosome, a cytoplasmic complex, relays external cues and activates the sigma B regulon. The stressosome is structurally well-characterized in Bacillus, but how it senses stress remains elusive. Here, we report a…
read more

Publication – Frontiers in Cellular and Infectectious Microbiology
Genome-Wide Transcriptional Start Site Mapping and sRNA Identification in the Pathogen Leptospira interrogans – Zhukova A, Fernandes LG, Hugon P, Pappas CJ, Sismeiro O, Coppée JY, Becavin C, Malabat C, Eshghi A, Zhang JJ, Yang FX, Picardeau M

Leptospira are emerging zoonotic pathogens transmitted from animals to humans typically through contaminated environmental sources of water and soil. Regulatory pathways of pathogenic Leptospira spp. underlying the adaptive response to different hosts and environmental conditions remains elusive. In this study, we provide the first global Transcriptional Start Site (TSS) map…
read more

News
Mon 30 Jan 2017 – Inauguration du C3BI

Seminar
Thu 15 Jun 2017 at 02:00 pm, Julien Dutheil will talk about Between chaos and determinism: the evolution of stochastic gene expression

Between chaos and determinism: the evolution of stochastic gene expression While often depicted as finely tuned programs, biochemical processes in the cell are subject to random fluctuations because of the small number of molecules involved. While this phenomenon was long recognised, it was only recently assessed at a genomic scale. In…
read more

Seminar
Thu 1 Jun 2017 at 02:00 pm, Julien Gagneur will talk about Genetic basis of gene regulation: genome-wide models and applications to diagnosis.

Genetic basis of gene regulation: genome-wide models and applications to diagnosis….
read more

Seminar
Thu 18 May 2017 at 02:00 pm, Tanja Stadler will talk about Pathogen dynamics through a phylogenetic lens – zooming into the spread of Ebola, Diphtheria, Tuberculosis, Influenza and HIV

Pathogen dynamics through a phylogenetic lens – zooming into the spread of Ebola, Diphtheria, Tuberculosis, Influenza and HIV…
read more