A population genetic interpretation of complex trait architecture in humans

EVENT : C3BI Seminars Main speaker : Guy Sella, from Department of Biological Sciences, Columbia University Date : 02-05-2019 at 02:00 pm Location : Auditorium Francois Jacob – BIME (26) ,Institut Pasteur, Paris Human genome-wide association studies (GWASs) are revealing the genetic architecture of anthropomorphic and biomedical traits, i.e., the frequencies and effect sizes of … Continue reading “A population genetic interpretation of complex trait architecture in humans”

Insights into early human migrations with modern and ancient genomic data

EVENT : C3BI Seminars Main speaker : Anna-Sapfo Malaspinas, from Department of computational biology, Université de Lausanne Date : 14-03-2019 at 02:00 pm Location : Auditorium Francois Jacob – BIME (26) ,Institut Pasteur, Paris Anna-Sapfo Malaspinas is assistant professor in the Department of computational biology of Université de Lausanne since 2017. Her work aims to … Continue reading “Insights into early human migrations with modern and ancient genomic data”

Using Systems Approaches to Understand the Mechanism of Disease

EVENT : C3BI Seminars Main speaker : Nevan Krogan, from Quantitative Biosciences Institute , UC San Francisco, USA Date : 11-04-2019 at 02:00 pm Location : Auditorium Francois Jacob – BIME (26) ,Institut Pasteur, Paris There is a wide gap between the generation of large-scale biological data sets and more-detailed, structural and mechanistic studies. However, … Continue reading “Using Systems Approaches to Understand the Mechanism of Disease”

Human gut resistome

EVENT : C3BI Seminars Main speaker : Amine Ghozlane, from HUB, C3BI Pasteur Date : 04-04-2019 at 02:00 pm Location : Auditorium Francois Jacob – BIME (26) ,Institut Pasteur, Paris The intestinal microbiota is considered to be a major reservoir of antibiotic resistance determinants (ARDs) that could potentially be transferred to bacterial pathogens via mobile … Continue reading “Human gut resistome”

Bayesian matrix factorization for drug discovery and precision medicine

EVENT : C3BI Seminars Main speaker : Yves Moreau, from Center for Computational Systems Biology, KU Leuven Date : 31-01-2019 at 02:00 pm Location : Auditorium Francois Jacob – BIME (26) ,Institut Pasteur, Paris Matrix factorization/completion methods provide an attractive framework to handle sparsely observed data, also called “scarce” data. A typical setting for scarce … Continue reading “Bayesian matrix factorization for drug discovery and precision medicine”