Publication – Concomitant emergence of the antisense protein gene of HIV-1 and of the pandemic

EVENT : C3BI Publication

Concomitant emergence of the antisense protein gene of HIV-1 and of the pandemic


Main speaker : , from Date : 07/10/2016 at Location : ,Institut Pasteur, Paris


HIV-1 is commonly assumed to have nine genes. However, in 1988 a 10th gene was suggested, overlapped by the env gene, but read on the antisense strand. The corresponding protein was named AntiSense Protein (ASP). Several pieces of evidence argue in favor of ASP expression in vivo, but its function is still unknown. We performed the first evolutionary study of ASP, using a very large number of HIV-1 and SIV (simian) sequences. Our results show that ASP is specific to group M of HIV-1, which is responsible for the pandemic. Moreover, we demonstrated that evolutionary forces act to maintain the asp gene within the M sequences and showed a striking correlation of asp with the spread of the pandemic.


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