Seminars – Conservation and co-evolution – 21 January 2016

EVENT : C3BI Seminars

Conservation and co-evolution: from sequence analysis to protein-protein interactions

Speaker : Alessandra Carbone, from  Laboratory of Computational and Quantitative Biology, CNRS Université Pierre et Marie Curie, Paris

     Time : 02:00 pm     

Starting Date : 21/01/2016     

Location : Retrovirus room – LWOFF (22), Institut Pasteur, Paris

Conservation and co-evolution: from sequence analysis to protein-protein interactions

In computational biology, a fundamental question is the extraction of evolutionary information from DNA sequences. Here, we consider protein sequences and structures. Given a family of protein sequences and the associated distance tree, we shall explain how a fine reading of the conservation and co-evolution signals between residues in sequences can be used to identify protein binding sites, mechanical and allosteric properties, protein-protein interactions. Based on this novel approach to coevolution analysis, we reconstructed the protein-protein interaction network of the Hepatitis C Virus at the residue resolution. For the first time, coevolution analysis of an entire virus was realised, based on a limited set of protein sequences with high sequence identity within genotypes. The identified coevolving residues constitute highly relevant predictions of protein-protein interactions for further experimental identification of HCV protein complexes. The method can be used for interaction predictions for other viral protein interaction networks.

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