EVENT : C3BI Seminars
Genetic basis of gene regulation: genome-wide models and applications to diagnosis.
Main speaker : Julien Gagneur, from Computational Biology Group – Technical University of Munich Date : 01/06/2017 at 02:00 pm Location : Auditorium Francois Jacob – BIME (26), Institut Pasteur, Paris
We are interested in understanding how gene expression is encoded in genomes, and how to leverage this knowledge to understand the basis of genetic diseases. To this end, we employ statistical modeling of ‘omics data and work in close collaboration with experimentalists. I will provide an overview of recent studies from our lab, covering work on RNA metabolism in S. pombe  and on mRNA stability in S. cerevisiae , and discussing the implications of TT-seq, a novel protocol suited to study nascent transcriptomes in higher eukaryotes . I will also report on a recent pilot study where we established RNA-sequencing as a powerful companion tool to genome sequencing for pinpointing molecular causes of rare genetic disorders . The talk will end with a discussion on future directions in computational modeling of cis-regulatory elements.References  Eser. et al, Determinants of RNA metabolism in the Schizosaccharomyces pombe genome, Molecular Systems Biology, 2016  Cheng, et al. Sequence features explain most of the mRNA stability variation across genes, bioRxiv  Schwalb et al. TT-seq maps the human transient transcriptome, Science, 2016  Kremer et al. Genetic diagnosis of Mendelian disorders via RNA sequencing, Nature communications (in press), bioRxiv
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