EVENT : C3BI Seminars
Know Thy Ancestors to Know Thyself: Improving Our Understanding of the Human Genome Using Computational Paleogenomics
Main speaker : Mathieu Blanchette, from Professor McGill University, Montreal – Computational Genomics Lab Date : 08/06/2017 at 02:00 pm Location : Retrovirus room – LWOFF (22), Institut Pasteur, Paris
Know Thy Ancestors to Know Thyself: Improving Our Understanding of the Human Genome Using Computational Paleogenomics The genomes of more than one hundred vertebrate genomes are now largely sequenced. How can one make use of this massive amount of evolutionary information to better understand the origin and function of portions of the human genome? In this talk, I will first discuss how the genomes of ancestral mammalian species can be reconstructed with surprisingly high accuracy from the genomes of extant species. I will then present how inferred ancestral sequences can be used to improve the detection of ancient evolutionary events such as transposable element and pseudogene insertions that have shaped mammalian genomes. Finally, I will then introduce algorithmic and machine learning approaches that make use of inferred ancestral DNA sequences to improve the accuracy of transcription factor binding site and micro-RNA target site prediction.
Due to security policy in Institut Pasteur, please register before if you plan to come to this meeting