Seminars – From Genome to Pan Genome

EVENT : C3BI Seminars

Paul Kersey


Main speaker : Paul Kersey, from Team Leader, Non-vertebrate Genomics, EMBL-EBI Hinxton, England Date : 21/12/2017 at 02:00 pm Location : Auditorium Francois Jacob – BIME (26) ,Institut Pasteur, Paris


Since the advent of genomics, the Genome Browser has proven an enduring and successful way of representing genomic information, using the paradigm of a linear map; and well-assembled and annotated genomes of experimental organisms have served as references for broader taxonomic groups. Ensembl, developed by EMBL-EBI, is one of the most widely used software platforms organising and serving data according tot his model.  But large scale projects to sequence populations of major species, and to more fully sample the taxonomy, are already commonplace, and accelerating in their ambitions. The logical ay to represent many (related) genome sequences is a graph; but graph-based visualisations may be confusing to users, and the majority of experimental discovery still takes lace in a small number of species.  In this talk, I will present how Ensembl is experimenting with new models to organise and display genomic data, more suited to a world where sequence is ubiquitous (with examples from vertebrates, vectors, pathogens and plants); and will explore not just technological, but also sociological and political aspects to developing a suitable data infrastructure for an era of genomic plenty.